Biobanking


Collaborative research facilities between the PBRU and University of Liverpool

Biobanking

The PBRU has its own dedicated ethically approved biobank. The biobank shares a common governance framework with the Liverpool Experimental Cancer Medicine Centre and so falls under the management umbrella of the University of Liverpool CR-UK Centre. The biobank lies physically within the Good Clinical Laboratory Practice (GCLP) facility and therefore benefits from the audit systems and environmental monitoring provided by the Good Clinical Laboratory Practice (GCLP) facility for trial samples, although the Biobank includes non trial material as well as material from pancreatic clinical trials.

Following the identification of novel markers using proteomics and genetic screening in samples from patients with pancreatitis and pancreatic cancer, we are substantially enlarging our biobanks of blood, tissue, pancreatic juice and urine from patients with (i) acute pancreatitis, (ii) chronic pancreatitis and (iii) pancreatic cancer. All samples are ethically collected and stored in accordance with the HTA and GCP/GCLP regulations and guidelines.

These biobanks are located in -80oC, and -150oC freezers in a dedicated freezer room in the GCLP Laboratory.  The temperature of the freezers is constantly monitored by a pharmagraph system. The pharmagraph alerts members of staff (over a 24 hour period, 7 days a week) if the temperature of the freezers deviate outside their operating limits as defined by OQ certification. Back up freezers are also provided in case of breakdown. Three independent electrical supplies provide energy for the freezers and all are secured by the Hospital generator. A Laboratory Information Management System (LIMS) is in place to record the storage and withdrawal of samples for research purposes. This provides an audit trail for samples in accordance with statutory instruments governing GCLP/GCP.

For futher details regarding GCLP at the University of Liverpool please click on the link to their website.   For futher information on being a part of the biobanks or any queries, please contact the lead specialist nurse, Sister Lorna Fleming via her contact details in Contact Us.